Serum Malondialdehyde and Uric Acid in Acute Myocardial Infarction: Comparative Levels and Inter-Marker Correlation

Abstract

Background Acute myocardial infarction (AMI) is one of the leading causes of morbidity and mortality worldwide. Oxidative stress plays an important role in myocardial injury and progression of cardiovascular disease. Malondialdehyde (MDA), a marker of lipid peroxidation, and serum uric acid, a metabolic antioxidant marker associated with oxidative injury, have been implicated in ischemic heart disease. Aim To assess serum uric acid and malondialdehyde levels in patients with acute myocardial infarction and to investigate their role as markers of oxidative stress in comparison with healthy individuals and correlation with troponin. Methods A hospital-based case–control study was conducted among 230 participants, including 115 AMI cases and 115 age-and sex-matched healthy controls. MDA measured by TBARS using HPLC, Troponin levels were estimated using a chemiluminescence-based immunoassay, Uric acid by uricase method. Since data distribution was non-normal, Mann– Whitney U test and Spearmen Rank Correlation Coefficient test were applied.