Flow Cytometry Assessment of Procoagulant Platelets Using A Dithiol Reactive Probe.

Procoagulant platelets in hemostasis and thrombosis

Procoagulant platelets in haemostasis and thrombosis.

Procoagulant platelets are characterized by sustained high cytosolic Ca2+, surface exposure of phosphatidylserine (PS) and P-selectin, and a balloon-shaped morphological transformation. These features strongly facilitate the generation of coagulation factor Xa and thrombin on the platelet membrane. Here, we provide a r...

Quantification of Human Platelet Clearance In Vitro and in Xenotransfused Animals.

Characterization of Platelet and Red Blood Cell Extracellular Vesicles by Spectral Flow Cytometry.

Splenic regulation of systemic platelet activation state.

Platelets are essential to prevent blood loss and to orchestrate inflammation. Thrombotic complications of vascular disease and hyperresponsive platelets are associated with adverse outcomes, yet physiological mechanisms counteracting systemic platelet activation are poorly defined. In mice, we found that the spleen fi...

Persistent Hypercoagulability and Further Characterization of Microclot Complexes in Long COVID

Background: Growing evidence suggests persistent thrombotic endothelial damage (together with elevated (fibrinaloid) microclot complexes (FMCs)) and immune dysfunction in the pathophysiology of Long COVID. Recently we proposed that there are different FMC phenotypes. Here we seek to determine the nature of these FMCs a...