An Efficient One Pot Synthesis And Antioxidant Activity of 6- (Benzylthio)-2H-Pyrazolo[3,4-d]Pyrimidine-3,4-Diamine

Abstract

A series of novel 6-(benzylthio)-2 H -pyrazolo[3,4-d ]pyrimidine-3,4-diamine (5a-j) have been designed and synthesized by condensation of 4-amino-2-(benzylthio)-6-(methylthio)pyrimidine-5-carbonitrile (3) with various hydrazine derivatives (4a-j) by using catalyst as anhydrous potassium carbonate and DMF solvent. Compound (3) was synthesized by reaction of S-benzylthiuronium chloride (1) and 2-(bis(methylthio)methylene malononitrile (2) under similar reaction condition which is used for title compounds. The newly synthesized compounds were characterized by IR, 1 H-NMR, 13 C-NMR and Mass spectral analysis. Additionally, the antioxidant activity of these synthetic substances was examined. Antioxidant activity results indicate that the majority of the substances exhibited strong action. This procedure gives the advantages of mild reaction condition, easy work up, short reaction time and high yield.