2- Exploring the Role of Vitamin D in Preventing DMBA-Induced Breast and Lung Cancers: Insights from a Preclinical Model

Abstract

Introduction: The role of vitamin D in the treatment of breast cancer has remained controversial. The purpose of this research was to investigate the prophylactic potential of vitamin D against breast carcinoma. Materials and Methods: Sprague-Dawley rats were used as models for DMBA-induced chemical breast cancer. Results: After seven months, the findings indicated a positive impact of vitamin D on breast and lung cancer prophylaxis, suggesting its potential in mitigating lung cancer. In comparison to mouse models, inducing breast cancer in Sprague-Dawley rats was more challenging, despite the clear effects of vitamin D and tamoxifen. The vitamin D dose was found to be hazardous. Additionally, the DMBA-induced cancer model showed inhibited vitamin D receptor expression. Conclusion: The vitamin D receptor pathway may play a crucial role in breast cancer development and treatment. Further research is needed to explore interspecies resistance to breast tumor carcinogenesis and to better understand the effects of vitamin D in cancer prevention.