Open access

TAOK3 inhibition constrains invasion, potentiates paclitaxel, and reprograms the tumor microenvironment toward anti-tumor immunity in cervical cancer

Marissa Iden Rachel Schmidt R. D. S. Mohammed Theresa A. Dlugi Roshan M. Kumar Shirng-Wern Tsaih Bakhtiyor Nosirov I. P. Kadamberi Sonam Mittal Shruti L Narayan William H. Bradley Beth Erickson Rebecca C. Czaja J. Felix Victor X. Jin Akinyemi I. Ojesina Sunila Pradeep Brian C. Smith Janet S. Rader

Jul 2026 · bioRxiv · 0 citations

Biology Medicine

TL;DR

Genetic or pharmacologic TAOK3 inhibition constrains tumor growth, potentiates paclitaxel, and remodels the microenvironment toward anti-tumor immunity, supporting TAOK3 as a potential therapeutic target and biomarker in ICC.

DOI PubMed Semantic Scholar

Read PDF

Similar papers

Open access Sep 2026

TET1 loss promotes malignant phenotypes in HeLa cells and is associated with altered PTEN–PI3K/AKT/mTOR signaling

Reduced TET1 expression was observed in SCC-restricted public cohorts, while TET1 depletion promoted malignant phenotypes in HeLa cells, which identifies a candidate signaling association that warrants validation through rescue experiments and locus-specific epigenetic studies.

Yan Liu, Lu-Jia Liu, Lu-Sheng Wang et al. · Frontiers in Oncology · 0 citations

Sep 2026

Abstract B006: Actin Cytoskeleton Dynamics in Tumor Cells Orchestrate Stromal Desmoplasia and Immune Evasion in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is defined by a dense, immunosuppressive tumor microenvironment (TME) enriched with extracellular matrix components, cancer-associated fibroblasts (CAFs), and diverse immune populations. ChIP-seq analysis of resected human PDAC identified MICAL2 as a super-enhancer–associat...

Bharti Garg, E. Mose, Briana Nyugen et al. · Cancer Research · 0 citations

Open access Sep 2026

SNX9 Orchestrates Lung Metastasis via EGFR-ERK Signaling and Actin Cytoskeleton Remodeling in Breast Cancer

Objectives: Sorting nexin 9 (SNX9) participates in endocytic trafficking and has been connected to several malignancies, but its involvement in breast cancer (BC) remains incompletely resolved. This work was designed to examine whether SNX9 supports BC progression and investigate signaling and cytoskeletal processes as...

Qingqing Liu, Lei Li, Kumar Ganesan et al. · Oncology Research · 0 citations

Open access Sep 2026

GAS5 Downregulation Promotes the Progression of Triple-Negative Breast Cancer by Regulating Tumor Cells-MDSCs Crosstalk

Background: Triple-negative breast cancer (TNBC) is exceptionally aggressive, with a high recurrence rate, resistance to chemotherapy, and a tendency to metastasize. The long non-coding RNA growth arrest-specific 5 (GAS5) is associated with TNBC progression; however, the specific mechanism still requires further explor...

Jun-Ze Du, Xin He, Ling-Feng Tang et al. · Cancers · 0 citations

Open access Aug 2026

Loss of LATS1 promotes immune evasion in colon cancer via YAP/TEAD-driven lactate metabolism reprogramming

The Hippo pathway components YAP and TAZ have been implicated in tumor immunity, but the role of upstream kinase LATS1 in colon cancer immune evasion remains unclear. This study aimed to investigate the function of LATS1 in regulating the tumor immune microenvironment (TME) of colon cancer. Human colon cancer tissues...

Zhe Zhang, Hankun Liu, Yuxuan Li et al. · Scientific Reports · 0 citations

Open access Sep 2026

MXRA5 promotes the progression and metastasis of breast cancer via activation of the epithelial-to-mesenchymal transition pathway

Elevated MXRA5 expression exhibited a positive correlation with advanced lymph node metastasis and impaired clinical prognosis, and its potential as a valuable prognostic biomarker and therapeutic target for managing metastatic disease is revealed.

Jian Wang, Jie Tang, Yaoxin Wang · Korean Journal of Physiology... · 0 citations