Detection MN1 Gene Expression in Sudanese Patients Diagnosed with Acute Myeloid Leukemia (AML)

Abstract

Background: The unchecked growth of immature blood cells in the bone marrow is the hallmark of acute leukemia, a potentially fatal hematologic cancer. The burden of acute leukemia is exacerbated in low-resource environments like Sudan by a lack of thorough cancer registries, regional healthcare inequities, and inadequate diagnostic skills. Meningioma 1 (MN1) overexpression (OE) is associated with the progression from myelodysplastic syndrome to acute myeloid leukemia (AML) and correlates with poor survival in AML patients. So this study conducted to detect the expression of MN1 among Sudanese patients diagnosed with AML.  Methodology: 100 AML patients recruited in this study, they were diagnosed with basic steps of diagnosis, which involved bone marrow, flow cytometer and complete blood count also conducted.MN1 detection was conducted through application of real time polymerase chain reaction (RT-PCR). Data analysis conducted by SPSS version 20.