Early serum neurofilament light chain may stratify optic neuritis severity and guide neuroprotective trial selection and guide neuroprotective trial selection.
Abstract
Optic neuritis, a common manifestation of multiple sclerosis, involves acute axonal injury and variable visual recovery. We evaluated whether serum neurofilament light chain predicts visual and structural outcomes after first-episode optic neuritis. Fifty-one patients (mean age = 33 years, 71% women) were followed for 24 ± 6 months with low-contrast letter acuity testing and optical coherence tomography. Adjusting for age and sex, higher baseline serum neurofilament light chain predicted greater inter-eye differences in retinal nerve fibre layer (-4.65 µm per SD, p = 0.02), ganglion cell/inner plexiform layer (-1.39 µm, p = 0.02) and 2.5% low-contrast letter acuity (-0.73, p = 0.05), but not high-contrast acuity. Early serum neurofilament light chain may stratify optic neuritis severity and guide neuroprotective trial selection.
Background: Optic neuritis (ON) is a common early manifestation of relapsing-remitting multiple sclerosis (RRMS), occurring at onset or during relapses. Recent MS criteria include the optic nerve, highlighting the need for accurate assessment. Optical coherence tomography (OCT) enables noninvasive evaluation of retinal...
Gabriela Mufarrej da Cunha Paixão, N. S. Meneguette, Eduardo Cukierman et al.· ANPAbstract_CBN26· 0 citations
The findings support a multimodal diagnostic model in which clinical examination, neuroimaging, retinal structural assessment, functional visual testing, and disease-associated antibodies provide complementary rather than redundant information.
M. García, Frida Desiree Lara Hernández, Jorman Fernando Cazorla Vinueza et al.· IECCMEXICO· 0 citations
Background and Objective: Uveitis occurs more frequently in multiple sclerosis (MS) than in the general population and is often clinically silent. We determined the anatomical types and visual field defect patterns of MS-associated uveitis, and compared the 24-month course of peripapillary retinal nerve fibre layer (pR...
Tomislav Vidović, Josip Knežević, Sonja Jandroković et al.· Journal of Clinical Medicine· 0 citations
Background: Pediatric optic neuritis often produces severe visual loss followed by substantial recovery, but its prognosis varies with the underlying inflammatory disorder. Normal high-contrast acuity does not exclude persistent contrast, field, or structural abnormalities. Objective: To examine presenting characterist...
Isabela Falco Ribeiro, Fernanda Pires Ribas Bueno, Lígia Crespo de Almeida et al.· Revista de Geopolítica· 0 citations
Purpose To compare the magnitude of visual recovery at 12 months after optic neuritis (ON), with long-term change as a secondary outcome, and distinguish numerical improvement from attained visual acuity (VA). Patients and Methods This retrospective cohort included 184 adults with idiopathic ON, AQP4-IgG-positive NMOSD...
Marin Pattanapattana, Pichaya Kulniwatcharoen, L. Hansapinyo· Clinical Ophthalmology· 0 citations
PURPOSE
To evaluate macular ganglion cell complex (GCC) thickness, retinal vessel tortuosity, visual function, and treatment effects in chronic Leber hereditary optic neuropathy (LHON) stratified by age at onset.
METHODS
Thirty-one chronic LHON subjects from the Swedish LHON registry were enrolled and grouped by age...
J. Hedström, Marie Nilsson, Sofia Fagerstrom et al.· Eye· 0 citations
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