Soluble Indicators of Endothelial Injury and Activation Emerge During Acute HIV Infection and Persist Despite Rapid Antiretroviral Therapy Initiation.

Interleukin-Driven Inflammation and Cardiovascular Risk in People Living with HIV: Mechanisms, Biomarkers, and Emerging Preventive Strategies

Evidence from the REPRIEVE randomized clinical trial demonstrated that pitavastatin therapy reduced major adverse cardiovascular events by approximately 35% in people living with HIV receiving antiretroviral therapy, highlighting inflammation-modulating strategies as a new foundation of cardiovascular prevention in thi...

ALDH Activity in Monocytes is Associated with Subclinical Coronary Atherosclerosis in Treated People with HIV-1

Temporal Dynamics of Circulating Syndecan-1 in Acute Ischemic Stroke and Their Association with Recanalization Therapy and Functional Outcomes.

Monocyte-associated C1q upregulation and complement activation contribute to vascular endothelial and multi-organ injury in severe dengue.

Dengue virus (DENV) infection causes a broad spectrum of clinical manifestations, ranging from self-limiting dengue fever (DF) to life-threatening severe dengue (SD). Increased vascular permeability and endothelial dysfunction are hallmarks of SD and contribute to plasma leakage, shock, and multi-organ injury, yet the...

Immune-inflammatory profiles, coronary artery disease, and peripheral artery disease in people with HIV.

BACKGROUND AND AIMS People with HIV (PWH) have high risk of coronary (CAD) and peripheral (PAD) artery disease independent of traditional risk factors. Single immune-inflammatory biomarkers provide limited insight into disease risk and phenotypes, whereas integrative profiling may reveal novel mechanisms. Here we inves...

ASSESSMENT OF ANTIOXIDANT CAPACITY, INFLAMMATION, AND DNA DAMAGE MARKERS INHUMAN IMMUNODEFICIENCY VIRUS PATIENTS WITH ASSOCIATED COINFECTIONS ON COMBINED ANTIRETROVIRAL THERAPY IN LAGOS STATE

Despite significant reductions in HIV-related morbidity and mortality due to the synergistic effects of combination antiretroviral therapy (cART), approximately 1.5 million deaths from human immunodeficiency virus (HIV) infection still occur annually. This study assessed the levels of total antioxidant capacity (TAC),...