Mar 2026· Science China Life Sciences· Vol 69, pp. 2700 - 2715· 0 citations· 57 references
Medicine
TL;DR
This hydrogel-based platform integrates multiple bioactive functions, presenting a promising strategy for the clinical management of DFUs, and exhibits pH-responsive behavior, along with potent antioxidant and hypoglycemic effects.
This in situ formed multifunctional hydrogel dressing effectively reduces excessive inflammation, enhances neovascularization, accelerates collagen tissue regeneration, and advances wound healing by improving the pathological microenvironment of diabetes.
Yunshu Yang, Bin Tang, Meng Zhou et al.· Materials Today Bio· 0 citations
The physicochemical properties of chitosan are summarized and the molecular mechanisms underlying hydrogel-mediated diabetic wound repair are systematically examined, including cation-mediated disruption of microbial membranes, Keap1/Nrf2-dependent antioxidant signaling, NF-κB-regulated immunomodulation, and VEGF-drive...
Hong-Yun Chen, Ying Xin, Cheng-Sheng Liu et al.· International Journal of Bio...· 0 citations
Diabetic refractory wounds are a prevalent and severe complication of diabetes, whose pathological progression is jointly mediated by multiple factors, including oxidative stress imbalance, chronic inflammation, impaired angiogenesis, bacterial infection, and biofilm formation. Current clinical hydrogel dressings gener...
Yan-Ling Li, Yu-Han Mao, Jie Zhang et al.· Gels· 0 citations
Diabetic chronic wounds, characterized by a unique pathological microenvironment including persistent hyperglycemia, excessive reactive oxygen species (ROS), bacterial infection, and sustained inflammation, exhibit notoriously impaired and delayed healing processes. This study developed a multifunctional hydrogel t...