TL;DR
The body composition profile of primary osteoporosis is characterized as a composite of changes, including proportional whole-body reduction of muscle and fat, preferential loss of trunk tissues, and significant fat infiltration in paravertebral muscles.
Assessment of bone mineral density (BMD), trabecular bone score (TBS), and muscle mass in adults with PIDs found reduced BMD and impaired TBS represented distinct, partially overlapping findings.
Low muscle mass is highly prevalent in hospitalized OVCF patients, and body composition phenotypes beyond BMI display modestly differentiated systemic inflammatory profiles, which warrant cautious interpretation and require prospective validation before clinical application.
Increases in ECF, ICF, and TBW were significantly linked to a lowered osteoporosis risk and enhanced BMD, which may aid clinicians in the early identification and intervention of patients at risk for bone loss.
Patients with obesity demonstrated site-specific reductions in trabecular bone quality, particularly in the lower lumbar spine compared with non-obese people, suggesting that metabolic dysfunction, not mechanical loading, influences bone fragility in obesity.
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