A plausible explanation for why conventional media fail is suggested and a metabolomics-guided framework for rational cultivation of host-associated microbiota across diverse systems is supported.
Gut microbiota is responsible for causing imbalance and metabolic disorder of gut. Mannan-oligosaccharide (MOS) has been used as a potential Prebiotic. A seven day study was performed to detect the impact of MOS on BALB/c mice and to determine changes in gut microbiota and there microbial populations. Mice were adminis...
Rahul Vashishtha, Suchitra Sharma, Amit Babu et al.· International Journal of Dru...· 0 citations
A high-throughput stool-derived in vitro culture is validated as a tractable proxy for an antibiotic altered gut microbiome to screen interventions and provides a practical tool for evaluating disrupted gut microbiota and for screening interventional compounds.
Wei-Miao Long, Avani Tantry, Julie K. Tran et al.· bioRxiv· 0 citations
Summary Gut microbiota act as beneficial symbionts of the hosts. Administration of α-glucosidase inhibitors (α-GIs) is considered to promote the microbiota’s carbohydrate availability, modulating short-chain fatty acid (SCFA) production. However, it remains unclear whether host-microbiota interaction differs depending...
The gut microbiota contributes to variation in susceptibility to enteric infection, but the underlying mechanisms remain poorly defined. Here, we leverage a natural model of disease resistance comparing Salmonella-resistant indigenous Tibetan chickens with susceptible commercial broilers to uncover conserved mechanisms...
Abstract Obesity is a globally prevalent metabolic disorder closely associated with gut microbiota dysbiosis. However, the precise roles of gut microbiota and microbial metabolism in this disease remain unclear. Through fecal metagenomic data mining and clinical cohort validation, we identified a gut bacterial strain w...