TL;DR
MRI volumetric assessment is a valuable adjunct to conventional MRI for detecting subtle hippocampal and hippocampal subfield volume loss in children with epilepsy, including those with normal conventional MRI findings.
The diagnostic performance of the hippocampal asymmetry index calculated using only the participant’s hippocampal volumes against a gold standard histopathological diagnosis of hippocampal sclerosis was evaluated and an open-source software tool for calculation of hippocampal asymmetry index was provided.
It is demonstrated that diffusion-based structural connectivity analysis can distinguish seizure-free from non–seizure-free TLE patients, highlighting the clinical relevance of hippocampus–temporal pole and hippocampus–thalamus pathways in postoperative outcomes.
Background: Idiopathic epilepsy (IE) is among the most frequent chronic neurological disorders of cats, but by definition it is associated with an unremarkable conventional brain MRI, leaving its temporal lobe pathophysiology poorly characterised. Objectives: To quantify interictal temporal lobe neurometabolite ratios...
Automated MRI volumetry may support the quantitative assessment of neurodegeneration in clinically defined AD and MCI, although these findings require external validation in larger, longitudinal, biomarker-characterized cohorts.
Ventral, medial, and posterior nuclei metrics show promise as imaging biomarkers of disease burden and seizure severity, thus encouraging further research into both structural and functional properties of thalamic nuclei in focal epilepsy.
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