Open access
Tie1 ectodomain cleavage governs vascular responses to inflammatory stimulation but is dispensable for angiogenic signaling
Miki Kamiyama
Jing-Jing Shi
L. Rinck
Yan-Zhu Lin
Yi-Fang Mao
Xiao-Wen Zhang
Ashik Ahmed Abdul Pari
Stephanie F. Preuss
Marlene Hoffarth
Gladys Hofsetz
Yu-Xi Di
Asmaa Zahran
Carleen Spegg
M. Riedel
Donato Inverso
Roxana Ola
Jun-Hao Hu
Kari Alitalo
H. Augustin
Mahak Singhal
Medicine
Abstract
Ectodomain cleavage of the vascular receptor Tie1 distinguishes the inflammatory from the angiogenic functions of Angiopoietin-Tie signaling, mechanistically uncoupling two fundamental vascular programs.