Review
Open access
Efficacy and Safety of CAR T‐Cell Therapy for Primary and Secondary Central Nervous System Lymphoma: A Systematic Review and Meta‐Analysis
Anfal Khan
A. A. Malik
Waqas Kareem
Mohammad Idrees
K. Kamil
Kinza Irshad
Zainab Baig
Anosha Yahya
Wardah Qureshi
Manzoor Ahmad
Bakht Bilanda
Medicine
Abstract
Patients with relapsed or refractory primary central nervous system lymphoma (PCNSL) and secondary central nervous system lymphoma (SCNSL) have limited treatment options and poor outcomes. CD19‐directed chimeric antigen receptor (CAR) T‐cell therapy has shown promising activity in this setting; however, the available evidence remains limited and heterogeneous. We performed a systematic review and meta‐analysis to evaluate its efficacy and safety.