Using Seqtometry-based analysis of mouse and human cDCs, distinct steady-state cDC1 gene programs enriched for either tolerance-associated or immune response-associated (pre-immunogenic) transcriptomic features that are present under homeostatic conditions in fully differentiated cDCs with divergent predicted immune functions are identified.
This study proposes that PGCCs represent an immune-adaptive polyploid survival state in which inflammatory and ontogenetic pathways are repurposed to support immune evasion and tumor persistence and provides a framework for therapeutic strategies aimed at dismantling the PGCC reservoir and preventing tumor relapse.
O. Anatskaya, Alexander E. Vinogradov· International Journal of Mol...· 0 citations
This comprehensive single-cell atlas delineates the dynamic landscape of human ILCs across diseases and reveals both conserved and disease-specific transcriptional programs of ILCs.
Songqi Duan, Shou-Bao Ma· Journal of Immunology· 0 citations
A single-cell atlas of approximately 10 million human peripheral blood mononuclear cells from 12 donors exposed to 90 cytokines is transformed into a multiscale model of cytokine response, and CytoCarto, a web application that projects cytokine profiles onto these networks to prioritize dysregulated programs, candidate...
HSPCs act as a systemic reservoir of inflammatory memory, while TNF blockade partially restores hematopoietic homeostasis, highlighting progenitor reprogramming as a therapeutic target.
Jin-Gyu Cheong, Chenyang Jiang, Muxue Du et al.· Journal of Immunology· 0 citations
HIF-1α is identified as a context-dependent checkpoint that connects hypoxia-responsive transcription to mitochondrial fitness and inflammatory plasticity in intestinal RORγt⁺ Treg.
Marcella Cipelli, E. M. da Silva, Luísa Menezes-Silva et al.· bioRxiv· 0 citations
A temporal atlas of IFN-γ stimulated transcriptomic dynamics in HeLa and HEK293T cells is provided, which reveals the shared core module and cell-specific patterns of their interferon responses.
Jiayao Jiang, Liangliang Zhang, Qian-Yi Yang et al.· Biology· 0 citations
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