Aug 2026· Nan fang yi ke da xue xue bao = Journal of Southern Medical University· Vol 46 8, pp.
1915-1925
· 0 citations
Medicine
TL;DR
PPT1 overexpression promotes GC progression by activating the ERK signaling pathway and thereby modulating lipid metabolism, suggesting its potential as a novel prognostic biomarker and a therapeutic target for GC.
Background Abnormal lipid metabolism promotes lung cancer progression. This study explores how TGFBR3 regulates fatty-acid-metabolism-related protein expression via the FATP2-ACSL1 axis to suppress lung cancer invasion and metastasis, and preliminarily assesses the potential clinical value of TGFBR3 and FATP2. Methods...
Tian Luo, Yuanyuan Wu, Nuoya Ma et al.· Frontiers in Oncology· 0 citations
Abstract: Background: Dysregulated expression of prolyl 4-hydroxylase subunit alpha 3 (P4HA3) has been identified in Colon cancer, breast cancer, head and neck cancers, etc. and is closely associated with tumor progression. However, its specific roles in gastric cancer (GC), particularly regarding alterations in metabo...
Tao Wang· Pakistan Journal of Pharmace...· 0 citations
The study identifies G6PD as a key metabolic gene linked to tumor progression; this finding not only offers potential insights into the molecular mechanisms of BRCA but also supports further exploration of metabolism-related therapeutic strategies.
Zhun Zhang, Ying Fu, Yu-Song Zhou et al.· Frontiers in Pharmacology· 0 citations
Bioinformatics analyses suggest that EPHX2 may participate in metabolic and tumor progression-related regulatory networks and may serve as a prognostic biomarker in LUAD.
Findings link FSCN1 to the AKT/mTOR/SREBP1/(FASN/SCD1) lipogenic axis and the p38 MAPK/PPARα/ACOX1 peroxisomal FAO pathway, implicating FSCN1 in lipid metabolic regulation and CRC progression, while suggesting a putative functional regulatory axis and a promising candidate therapeutic target for CRC.
HIST1H4L was significantly upregulated in SCLC tumors versus normal tissues and enriched in DNA transcription-related pathways and correlated with poor patient survival; critically, high HIST1H4L expression correlated with poor patient survival.
Shi-Cheng Feng, Min Feng, Zhi-Qiang Lu et al.· Frontiers in Oncology· 0 citations
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