This review will highlight recent metabolomics discoveries on unravelling the complex phytochemical composition of selected medicinal plants in producing neuroprotective bioactive compounds and therapeutic potential to combat neurodegenerative related disease especially Alzheimer’s disease (AD).
Metabolomics is a new-generation omics technology emerging after genomics, transcriptomics, and proteomics, It focuses on all small-molecule metabolites with molecular weights below 1 kDa within biological systems, providing a direct reflection of the terminal phenotypic changes in the physiological and pathological st...
Chun-Lei Xie, Cong-Cong Tang, Qi Tang et al.· Clinical Medicine and Pharma...· 0 citations
Natural products remain significant sources of bioactive compounds for agriculture and medicine, though conventional discovery approaches are constrained by complex biosynthetic pathways, low metabolite yields, rediscovery of known compounds and labour-intensive screening. The combination of multi-omics technologies su...
Akash Kishor Rokade, Ha Nguyen· Vietnam Journal of Biotechno...· 0 citations
Degenerative diseases impose a growing global health burden, whereas currently available therapies remain limited by adverse effects, drug resistance, and variable clinical efficacy. This critical narrative review used a structured, database-informed search of PubMed, Scopus, and ScienceDirect to identify original stud...
Indah Solihah, A. N. Garmana, N. Happyana et al.· Biomedicine & pharmacotherap...· 0 citations
Background: Alzheimer’s disease (AD) is a complex neurodegenerative disorder with a global impact, highlighting an urgent need for effective dietary therapeutic agents for the development of brain-healthy functional foods and medicines. This study focuses on the edible red alga Pterocladiella capillacea from Zhanjiang,...
Mei-Cai Yue, Long-Jian Zhou, Wan-Rong He et al.· Nutrients· 0 citations
These multi-target interactions suggest that S. samarangense phytochemicals can modulate key DR-associated pathways, and exhibits promising multi-target activity against Diabetes retinopathy.
Arun Kandhan, B. Mathew, Sundarrajan Thirugnanasambandam· Frontiers in Bioinformatics· 0 citations
Type 2 diabetes mellitus (T2DM) is a highly prevalent and rapidly expanding global metabolic disorder. Medicinal mushrooms have recently been proposed as promising functional foods, owing to their broad range of bioactive compounds, including β-glucans and other polysaccharides, triterpenoids, phenolic metabolites, ste...
Radoslav Z. Pavlović, J. Novaković, G. Ramenskaya et al.· Frontiers in Nutrition· 0 citations
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