Aug 2026· Molecules· Vol 31, pp. 2695· 0 citations· 44 references
Medicine
Abstract
While previous studies have illuminated the behavior of poly(gallol methacrylate)-block-poly(N-phenylmethacrylamide) copolymers (PM-b-PNP) in polar alcoholic mixtures, their performance in non-polar environments remains an uncharted territory. In this study, full-atomistic molecular dynamics (MD) simulations were first employed to investigate the conformational behavior and aggregation of experimentally relevant homo- and block copolymer architectures in heptane. The theoretical findings were subsequently supported through experimental studies using polymers synthesized via controlled reversible addition fragmentation chain transfer (RAFT) polymerization. Our results highlight the critical role of intramolecular hydrogen bonding in stabilizing specific conformations and helix-like structures of PNP homopolymers and the leading role of attractive van der Waals interactions in the aggregation of block copolymers.
Directing the self-assembly of small organic molecules into anisotropic nanoparticles without relying on metal coordination remains a fundamental challenge. Here, we show that controlled evaporation of aqueous solutions of a small-molecule amphiphile composed of a π-conjugated aromatic core functionalized with oligo(...
R. Arumugaperumal, Amar Raj, R. Puttreddy et al.· ACS Materials Letters· 0 citations
Conjugated rod-coil block copolymers provide a promising route to decouple the optimisation of ionic and electronic transport in organic electrochemical transistors (OECTs). Poly(3-alkoxythiophene) (P3AOT)-based rod-coil block copolymers with precisely tuned polyethylene glycol (PEG), and poly(L-lactide) (PLLA) coil bl...
Jun-Fu Tian, Wentao Shan, Rachael Found et al.· Advances in Materials· 0 citations
The effect of B homopolymer adding on the aggregation behavior of amphiphilic coil/rod/coil BAB triblock copolymers was studied using lattice self-consistent field theory. It depends on the length of the hydrophobic rod block and copolymer concentration. Compared with the solutions, at low concentrations, homopolymer a...
X.-G. Han, H. Zhang, Z.-H. Sun et al.· 0 citations
Thermoplastic elastomer gels constitute a valuable class of composition-tunable materials that are typically fabricated from styrenic ABA triblock copolymers (i) possessing a morphology with A-dispersions in a B-matrix and (ii) physically modified with a B-selective, low-volatility oil to controllably alter mechanica...
Kacie M. Wells, Alexey A. Gavrilov, Ivan Kuzmenko et al.· Macromolecules· 0 citations
Access to smaller phase domain dimensions requires reducing the degree of polymerization, which weakens segregation and increases the importance of strong segmental incompatibility; however, the same chemical contrast can impede direct sequential block copolymerization through differences in solvent affinity. Here, w...
Yi-Fan Tian, Xu-Le Yang, Wei-Jia Fan et al.· ACS Macro Letters· 0 citations
The amphiphilic block copolymer, poly{2‐[2(2‐methoxyethoxy)ethoxy]ethyl acrylate}‐block‐polystyrene (PMEEEA‐b‐PS), is a well‐designed polymer that forms a microphase‐separated structure oriented perpendicular to the film surface via simple thermal annealing. However, the preferential segregation tendency of one compone...
