NOP2 Exacerbates Pulmonary Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease by Inducing Neutrophil Extracellular Traps Mediating M1 Macrophage Polarization

GNG7 attenuates inflammation and modulates macrophage function via the NF-κB/NLRP3 inflammasome pathways in Poly I:C-induced acute lung injury.

Findings suggest that GNG7 helps limit Poly I:C induced macrophage inflammation, possibly through NF-κB/NLRP3-related signaling.

PKM2 associated alveolar macrophage remodelling is linked to defective efferocytosis of apoptotic neutrophils in LPS induced acute lung injury.

BACKGROUND Impaired clearance of apoptotic neutrophils by alveolar macrophages (AMs) may sustain inflammation in acute lung injury (ALI). Although PKM2 regulates macrophage inflammatory responses, its relationship with AM efferocytic dysfunction during ALI remains unclear. METHODS We integrated time-course single-cel...

ANKRD22 contributes to NF-κB-associated inflammatory responses in alveolar type II epithelial cells during PM2.5-triggered airway inflammation

Background PM2.5 causes multifaceted detrimental effects on human health. Alveolar type II epithelial (AT-II) cells serve critical function in PM2.5-induced airway inflammation. However, the mechanism remains unclear. Methods ANKRD22 expression in AT-II cells was assessed in a PM2.5-induced mouse airway inflammation mo...

Xiaoqinglong decoction improves chronic obstructive pulmonary disease by modulating PI3K/AKT-NRF2/NF-κB-mediated senescence-associated phenotypes.

TRIM27 enhances NF-κB/MAPK activation by ubiquitinating and degrading TRAF3 to drive asthma-induced airway inflammation

TIPE2 modulates macrophage polarization via targeting Rac1/NF-kB and PI3K/AKT pathways

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disorder that affects up to 12% of the general population. It is associated with significant morbidity and a considerable burden on the healthcare system. Tumor necrosis factor -induced protein 8-like 2 (TIPE2) is an immune-related protein...