Oct 2026· JAMA Network Open· Vol 9, pp. e2639409· 0 citations· 33 references
Medicine
TL;DR
The findings suggests that the association between epigenetic aging and neurodevelopment among children born preterm is context dependent and can vary based on the presence of preterm risk factors.
Abstract
Key Points Question What is the association among preterm risk factors, epigenetic aging, and neurodevelopmental outcomes in children born preterm? Findings In this cohort study with 102 children, epigenetic aging, higher maternal education level, extreme prematurity, and severe brain injury were associated with neurodevelopmental outcomes. The association between epigenetic aging and motor outcomes was modified by severe brain injury. Meaning The findings suggests that the association between epigenetic aging and neurodevelopment among children born preterm is context dependent and can vary based on the presence of preterm risk factors.
Preterm preschoolers with neurodevelopmental impairments showed a systemic profile of biological immaturity (reduced subcutaneous adiposity, lower neutrophil and platelet counts and a persistence of transitional B cells).
Armida I. Bahena-Delgado, Carmen Hernández-Chávez, S. Martínez-Medina et al.· Frontiers in Immunology· 0 citations
Background: Preterm infants are at a higher risks of neurodevelopment impairments because of metabolic and nutritional challenges during early life period. EPN plays a vital role in treating NICUs which helps in development and growth of infants. Researchers have not yet determined how EPN works in neurodevelopment at...
A. Hashmath· Journal of Population Therap...· 0 citations
Maternal immune activation (MIA) and preterm birth have both been associated with increased risk of autism spectrum disorder but their combined impact in preterm children is unclear. This prospective population-based cohort study used data from the French EPIPAGE-2 study, which included liveborn infants delivered at...
P. Ellul, L. Marchand-martin, Fanny Salmon et al.· Translational Psychiatry· 0 citations
Background Exploratory behavior is a foundational mechanism through which infants acquire motor, cognitive, language, and socioemotional competencies. Despite a growing body of evidence, no scoping review has comprehensively mapped the multidimensional determinants — including socioeconomic, environmental, parenting, a...
Abhishek Sankapal, Vinuta Deshpande· International Journal of Dru...· 0 citations
Objective: Young children with congenital heart disease (CHD) are at risk for neurodevelopmental impairments and deficits in adaptive functioning that impact quality of life. Social determinants of health, such as neighborhood disadvantage, contribute to adverse post-surgical outcomes, decreased healthcare access, an...
I. A. Iverson, C. Anton, A. Canas et al.· Archives of Clinical Neurops...· 0 citations
ABSTRACT Although the survival rates of preterm infants have markedly improved, their neurodevelopmental outcomes remain poor. Historically, brain injury in preterm infants has been recognized as intraventricular hemorrhage or white matter injury, often resulting in cerebral palsy. More recently, increasing attention h...
