Terminal Modification Reprograms Supramolecular Organization of Integrin Ligand Assemblies to Shape Cell Migration

Adhesion gateway: decoding mechanobiological cues for cytoskeletal reconfiguration

Programmable DNA Assemblies Reconstitute Supramolecular Protein Function

Designer CASCAD (CARD Assembly on SCAffold DNA), a self-assembled DNA nanoplatform that spatially organizes caspase recruitment domains (CARDs), exhibiting catalytic intracellular caspase-9 activation, is reported, establishing CASCAD as versatile and programmable DNA nanomaterial for reconstructing signaling pathways...

Mechanical Quantification of Molecular Interactions Reveals Spatiotemporal Fluctuations on the Cell Surface

The cell membrane hosts initial interactions between receptors and ligands for subsequent cellular functions. However, how the membrane spatiotemporally regulates binding mechanics in living cells remains unclear. Using magnetic tweezers, we developed a single-molecule platform to reveal that dissociation forces of i...

Metalloprotein-inspired design of synthetic polymers.

Metal ion recognition in proteins emerges from coordinated effects of sequence patterning, hierarchical structure, and dynamic plasticity that promote high-affinity, ion-selective binding. Synthetic polymers, by contrast, offer broad chemical tunability but lack unified frameworks linking copolymer sequence and organiz...

Topology-Programmed Peptide Architectures Orchestrate Durable Tumor Targeting and Cascade Antitumor Immunity

Peptide supramolecular systems offer recognition and biocompatibility for precision theranostics, yet their in vivo performance is limited by insufficient structural stability, poor retention, and loss of accessible recognition interfaces under physiological perturbations. Herein, a topology-programmed supramolecular...

A Covalent Brush-on-Brush Polymer Programs Ordered Intracellular Activation of a Mitochondria-Disrupting Peptide.

Can the order in which a material encounters distinct biological environments be encoded directly into its covalent architecture? Intracellular peptide effectors acting at defined subcellular sites require activation logic that follows this order, yet many responsive carriers couple multiple functional changes to one t...