This study characterized the morphology of platelet-like particles using nanoparticle tracking analysis, transmission electron microscopy, and immunofluorescence, and suggests that platelets fulfill the current minimal criteria for EVs, raising the possibility that they could be conceptually viewed as a specialized EVs subset rather than conventional blood cells.
With the exception of tractopods, all PMPTs - including PITTs and FLIPRs - support leukocyte adhesion, thereby influencing immune cell recruitment and activation, and strongly indicates a role of PMPTs in the crosstalk between hemostasis and inflammation.
M. Wolff, C. Owczarek, A. Greinacher· Journal of Thrombosis and Ha...· 0 citations
The history of EV research reflects a remarkable transition from observations of poorly understood extracellular particles to the recognition of EVs as key modulators of biological communication and potential therapeutic systems.
R. Miron, Paras Ahmad, A. Sculean· Periodontology 2000· 1 citation
Platelet α-granules contain hundreds of bioactive proteins that regulate thrombosis, inflammation and tissue repair. The interplay between α-granule secretion and platelet biomechanics is central to platelet function but remains incompletely understood. Here we combined complementary super-resolution microscopy methods...
Smita Patil, Joran Deschamps, M. Garrè et al.· bioRxiv· 0 citations
Extracellular vesicles (EVs) have dominated research on intercellular communication for decades. However, the discovery of exomeres in 2018 revealed that conventional exosome preparations contain large quantities of long-overlooked non-membranous nanoparticles. Additional non-vesicular extracellular nanoparticles (NVEP...
Heng-Xiang Liu, Zi-Shuai Chen, Hai He et al.· Biomolecules· 0 citations
The plasma membrane encodes critical information about cellular identity and phenotype, yet detailed characterization of this complex interface remains technically challenging in whole cells. Giant plasma membrane vesicles (GPMVs), generated via chemically induced blebbing, offer a simplified yet biochemically rich m...
K. Pogoda, Karolina Chrabąszcz, P. Deptuła et al.· Scientific Reports· 0 citations
Caveolae are 50-100nm, cholesterol- and sphingolipid-enriched invaginations of the plasma membrane, assembled from caveolin and cavin proteins. They are not generic vesicles distributed equally across mammalian tissues, but cell-type-specific membrane organelles whose abundance, molecular composition and physiological...
M. Rusu, Iuliana Zamfir, Ivan Varga et al.· International Journal of Bio...· 0 citations
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