Aug 2026· Interdisciplinary Sciences Computational Life Sciences· 0 citations· 58 references
Medicine
TL;DR
An adaptive wavelet-Transformer interpretable network (AWTI-Net), an integrative and interpretable framework combining multi-scale wavelet-based sequence encoding, LSTM-driven temporal modeling, a frequency-aware memory Transformer, and an adaptive decision-making mechanism to capture hierarchical lncRNA variant features, highlighting its potential as a robust and interpretable tool for genetic studies of disease-associated noncoding variation.
Findings suggest that CDELDA can support content-based candidate prioritization under both-cold evaluation, and provide candidates for biological follow-up, with disease-specific relevance requiring independent validation.
Sanguk Kim, Taehyeon Yun, Jihwan Ha· Biomedicines· 0 citations
Abstract Non-coding RNAs (ncRNAs), once considered genomic dark matter, are now established as key regulators of gene expression with widespread roles in cellular homeostasis and disease. In cancer, ncRNA expression is frequently and systematically dysregulated, and many of these molecules circulate in stable, protecte...
This thesis demonstrates that the integration of refined isomiR and tRF profiles within targeted liquid biopsy populations (TEPs and PD), supported by advanced bioinformatics tools like miRGalaxy, significantly enhances the accuracy and sensitivity of cancer diagnosis.
This chapter offers a comprehensive, reproducible protocol for identifying and clinically validating circulating long noncoding RNA (lncRNA) biomarkers for NAFLD and NASH.
M. A. Hussein, Anwar Abdelnaser· Methods in molecular biology· 0 citations
A structured multi-layer interpretation framework is proposed that links computational outputs across data-level processing, epigenomics-informed integrative regulatory modeling, and multi-omics-informed clinical interpretation, enabling traceable and mechanistically interpretable clinical inference.
M. Srivastava, Pratik Kumar, Ankita Chouhan et al.· Academia Molecular Biology a...· 0 citations
This approach efficiently decodes the complex interactive topologies between lncRNAs and human diseases through topology-aware network representation and equilibrium-driven distribution alignment and provides more effective theoretical guidance for interpreting lncRNA-mediated cellular control systems and discovering p...
Jia-Jia Liu, Mu-Gang Lin, Ling-ling Zhu et al.· Bio Systems· 0 citations
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