TL;DR
Apigenin, as the core active ingredient of TMG, was demonstrated to target GSK3β/APC to promote β-catenin degradation and inhibit the activation of the Wnt/β-catenin pathway, thereby exerting anti-CRC effects.
INTRODUCTION Diosmetin, a naturally occurring flavonoid abundant in plants such as chrysanthemums, lemons, and oranges, has been reported to exhibit diverse antitumor properties. However, its potential efficacy against bladder cancer remains unexplored. This study aims to investigate the anti-bladder cancer effects of...
This study provides reliable experimental evidence for the development of genistein as a potential adjuvant therapeutic agent for CRC treatment by revealing that genistein dose-dependently inhibited CRC cell proliferation without obvious cytotoxicity to normal colon cells.
Erchen Decoction and its key bioactive constituent, Rhoifolin, exert potent anti-tumor effects against CRC by suppressing the Adcy2/cAMP/PKA signaling axis.
BACKGROUND Colorectal cancer (CRC) has become one of the most common causes of cancer mortality worldwide. Accumulating studies suggest that the progressive up-regulation of Wnt/β-catenin signaling is a crucial hallmark of CRC, and this pathway is involved in the development and maintenance of colorectal cancer stem ce...
Colorectal cancer, characterized by its invasive behavior, frequent recurrence, and limited responsiveness to standard treatment, necessitate the advancement of innovative therapeutic approaches. Isoliensinine (ISO), a natural bisbenzylisoquinoline alkaloid, has demonstrated broad antitumor activity. However, its e...
Aliflorin suppresses BC progression by inhibiting the HINT2/NLRP3 signaling pathway, suggesting HINT2 is a viable biomarker and Al a promising therapeutic agent for BC treatment.
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