Water-Mediated Synthesis, Antimicrobial Evaluation, Molecular Docking, and ADMET Profiling of Novel 2-Amino-3,5-dicarbonitrile-6-sulfanylpyridines

Mechanochemical Synthesis, Characterization, and Biological Evaluation of N-Cyclohexyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxamide Derivatives

SYNTHESIS, ANTIMICROBIAL EVALUATION, MOLECULARDOCKING, AND TOXICITY PREDICTIONOFN-BENZYLIDENE-1,2,4-TRIAZOLO[4,3-b]PYRIDAZINEDERIVATIVES

The comprehensive results based on the experimental and computational approaches revealed that these novel hybrids (5a-5k) represent promising scaffolds for the development of antimicrobial and other useful therapeutic drugs, thereby contributing to United Nations Sustainable Development Goal 3: Good Health and Well-be...

Synthesis, characterization and molecular docking studies of novel 6-Imino-2-Methyl-4-substituted- 6H -1,3-Thiazine-5-Carbonitrile derivatives as potential antibacterial agents

Favourable binding energies and significant intermolecular interactions highlight these thiazine derivatives as promising leads for further antibacterial development.

Design, Synthesis and Antibacterial Evaluation of (E)-N-(3-methyl-6-nitroquinoxalin-2-yl)-4-((1-phenylethylidene) Amino) Benzenesulfonamide Derivatives

Antibiotic resistance has increased the need to investigate new antibacterial scaffolds. This study synthesized  a series of quinoxaline sulfonamide Schiff base derivatives, designated 1a–h, and evaluated their antibacterial activity against selected bacterial strains. The compounds were prepared through the reaction o...

One-Pot Synthesis of Azolylmethanesulfonamido-Substituted Oxadiazoles, Thiadiazoles, and Triazoles as Antimicrobial, Antioxidant, and Anticancer Agents Supported by Molecular Docking Studies

Schiff Base Derivatives of Benzothiazole and Benzamide as Promising Antimicrobial Agents: Integrated In Silico and In Vitro Evaluation.

Antimicrobial resistance (AMR) remains a critical global health challenge, demanding new scaffolds with potent and broad-spectrum activity. In this work, a library of Schiff-base derivatives of benzothiazoles (2a-2f) and benzamides (5a-5i) was designed, synthesised via a microwave-assisted approach, and comprehensively...