Synthesis of 1,3-Diaryl-4-Functionalized Pyrazoles Bearing Benzenesulfonamide as Promising Anti-MRSA Scaffold: Design, Synthesis, In Vitro and In Silico Studies
ADME-Tox study showed that the structure modification increases the drug likeness (better pharmacokinetic and less toxicity) in comparison to compound II, while the docking study showed for the first time that 1,3-Diaryl-4-Functionalized Pyrazoles can exert its reported activity on bacterial cell wall synthesis through undecaprenyl pyrophosphate Synthase (UPPS) enzyme.
Pyrazole-1,3,4-thiadiazine-linked isoxazole derivatives, specifically 6n and 6o, are identified as potential candidates for the development of novel antibacterial and antibiofilm drugs.
Reddycherla Venkatesh, K. Chennakesavulu, Reddy G. Ramanjaneya· Current Organic Synthesis· 0 citations
Promising compounds like SBB-2, SBB-3, SBB-5, SBB-6, and SBB-7 exhibit favourable physicochemical properties, high drug-likeness, solubility, and a non-toxic profile, making them strong candidates for further development of a promising drug.
D. Upadhyay, Drashti Thanki, C. Somaiya· Current Organic Synthesis· 0 citations
The promising potential of 48 as a potent agent for the treatment of MRSA infections was shown, with a sustained antibacterial effect, potent biofilm-disrupting and biofilm-inhibitory activity, a long half-life, and a favorable preliminary safety profile in the models tested.
Peng-Jie Li, Ji-Xiu Gao, Hao-Ran Li et al.· Journal of Natural Products· 0 citations
Among the synthesized quinoxaline sulfonamide Schiff base derivatives, compound 1g showed the strongest overall killing-rate performance reported in the study, indicating that the synthesized quinoxaline sulfonamide Schiff bases possess measurable antibacterial activity under the experimental conditions used.
F. Taiwo, O. Abioye, O. B. Omoyeni et al.· Journal of Pharmaceutical Re...· 0 citations
The design and synthesis of ten disubstituted tetrazole derivatives (5a–5j) via a one-pot, four-component Ugi-azide reaction (UGI-4CR) employing 2-(4-chloro-2-formylphenoxy)acetonitrile, variously substituted primary aromatic amines, trimethylsilyl azide, and tert-butyl isocyanide in anhydrous methanol at ambient tempe...
R. Gohil, Anjalee R. Khoyanee, Hetal Ramani et al.· Discover Chemistry· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
