An immunocompromised man in his 70s with a 15-year verrucous plaque on the right hallux initially suspected as squamous cell carcinoma is described and it is suggested that MAL-PDT may be a useful adjuvant to amphotericin B in complex CL caused by the L. donovani complex.
Abstract
Cutaneous leishmaniasis (CL) caused by the Leishmania donovani complex is uncommon in Europe and can masquerade as malignancy. We describe an immunocompromised man in his 70s with a 15-year verrucous plaque on the right hallux initially suspected as squamous cell carcinoma. Histology revealed macrophages packed with amastigotes; PCR confirmed L. donovani complex infection and serology was strongly positive. Staging excluded mucosal and visceral disease. Systemic liposomal amphotericin B achieved partial regression. Because of persistent hyperkeratosis and the acral site, adjuvant methyl-aminolevulinate photodynamic therapy (MAL-PDT) was added and was well tolerated. One month after the final session, the lesion showed near-complete re-epithelialisation with functional recovery. This case underscores the importance of early biopsy in atypical CL and suggests that MAL-PDT may be a useful adjuvant to amphotericin B in complex CL caused by the L. donovani complex.
Leishmaniasis is a tropical infection that usually presents as a cutaneous, mucocutaneous, or visceral disease. The most common organs involved in visceral leishmaniasis are the liver, spleen, and bone marrow; involvement of the stomach is rare, with only a few cases reported to date.
We present a 45-y...
A. ur Rehman, Alexander Banerjee, Bennett Christie-Nguyen et al.· ASM Case Reports· 0 citations
ABSTRACT. Cutaneous leishmaniasis is a neglected vector-borne disease caused by Leishmania spp., with viable parasites potentially persisting after clinical cure. Immunosuppressive therapies may favor reactivation of latent infection. The case of a 62-year-old Brazilian woman with a 25-year history of rheumatoid arthri...
Regina Maia de Souza, F. Tuon, A. Nicodemo et al.· American Journal of Tropical...· 1 citation
Background Oral epitheliotropic T-cell lymphoma (ETCL) is an uncommon form of canine cutaneous lymphoma involving the oral mucosa and mucocutaneous junctions. Information regarding optimal treatment strategies and prognosis is limited. Electrochemotherapy (ECT) has demonstrated efficacy against various cutaneous and su...
Makoto Akiyoshi, M. Hisasue· Frontiers in Veterinary Scie...· 0 citations
INTRODUCTION
Leishmaniasis encompass a heterogeneous spectrum of neglected tropical diseases, with clinical course and treatment outcomes strongly influenced by Leishmania species and geographic setting. Despite recent advances, their pharmacological management remains challenging.
AREAS COVERED
This review examines...
R. N. Sampaio, João Vitor Matachon Viana, Fellipe Magela de Araújo et al.· Expert Opinion on Pharmacoth...· 0 citations
Cutaneous leishmaniasis is a zoonotic disease endemic in several areas of the Mediterranean basin, including Liguria, characterized by heterogeneous clinical and histological features that can complicate diagnosis. We report the case of a male patient with a history of frequent exposure to woodland areas, presenting wi...
Associazione Dermatologi-Venereologi Ospedalieri Italiani e della Sanità Pubblica· Dermatology Reports· 0 citations
Systemic treatment options for CL show variable efficacy, and comparative evidence remains insufficient to support therapy recommendations, despite the promising cure rates for miltefosine and L-AmB.
Maximilian Egg, D. Wienand, L. Harpain et al.· Journal of the European Acad...· 0 citations
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