Salvianolic acid B suppresses non-small cell lung cancer growth by promoting Nrf2 proteasomal degradation and triggering autophagy-dependent ferroptosis.

USP7/SETDB1 promotes non-small cell lung cancer progression by regulating ferroptosis via NRF2/SLC7A11/GPX4 axis.

11-Oxo-mogroside V attenuates lung adenocarcinoma progression by disrupting metabolic homeostasis and suppressing TGFβ2/Myc-dependent oncogenic signaling.

BACKGROUND Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality worldwide, with nonsmokers comprising a notable proportion of cases. The complexity of its molecular pathogenesis poses substantial challenges for the development of effective therapeutic strategies. Traditional Chinese medicine-derive...

Medicarpin triggers Fas cell surface death receptor-mediated apoptosis by inhibiting epidermal growth factor receptor/signal transducer and activator of transcription 3 pathway and protective autophagy in liver cancer.

BACKGROUND Liver cancer remains the leading cause of cancer-related mortality worldwide, highlighting the need for novel therapeutics. Medicarpin is a pterocarpan, an isoflavonoid derivative, isolated from Spatholobus suberectus Dunn, exhibiting diverse bioactivities, yet its anticancer potential in liver cancer and un...

Lentinan Exerts Antitumor Activity in Non-small Cell Lung Cancer through P53-mediated Cytochrome c Release and Caspase Activation: A Preclinical Study.

INTRODUCTION Lentinula edodes is regarded as a functional food and dietary supplement due to its significant nutritional and medicinal value. Lentinan (LTN) was reported to enhance immune function and exhibit antitumor activity. Although numerous studies have confirmed the inhibitory effect of LTN on tumors in vitro, i...

Marbofloxacin Suppresses Breast Cancer Growth Through Oxidative Stress and Metabolic Reprogramming with Predicted HSP90AA1–EGFR Network Modulation

Background: Drug repurposing represents an accelerated and cost-effective approach to discovering novel oncologic therapeutics. Here, we investigated the anticancer potential and underlying mechanisms of marbofloxacin (MBF), a veterinary fluoroquinolone (FQ), against breast cancer (BC) cells. Methods: The cellular impa...

Bufalin Induces Ferroptosis in Triple-Negative Breast Cancer via Inhibition of the NRF2/HO-1/GPX4 Pathway.

Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer characterized by poor prognosis and limited therapeutic options, remains a major clinical challenge. Bufalin, a principal bioactive component of Venenum Bufonis, exhibits potent anticancer activity against breast cancer. Nevertheless, th...