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TREM2 mediates macrophage suppression of NLRP3 inflammasome pathway to promote non-small cell lung cancer progression

Ruocheng Sha Haonan Wang Pei-Li Chen Xue-Mei Wei Hao-Yi Li Zhong-Zheng Jiang Chen-Yang Liu Ming-Ming Liu Fengming Tian Xiu-Min Ma
Jul 2026 · Molecular and Cellular Biochemistry · Vol 481, pp. 3961 - 3974 · 0 citations · 35 references
Medicine

TL;DR

This study elucidates the mechanism by which TREM2 inhibits NLRP3 inflammasome activity in NSCLC, thereby promoting tumor immune evasion and progression and suggests that TREM2 could serve as a promising target for therapeutic interventions in NSCLC treatment.

DOI PubMed Semantic Scholar
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