TL;DR
In vivo experiments demonstrated that exosomes from EHF-silenced M2 macrophages inhibited tumor growth and downregulated proliferation markers, and highlighted the EHF/FGFR1 axis as a novel molecular link between macrophages and NSCLC cells.
This study uncovers a divergent metabolic program mediated by HMGB1 and demonstrates its role in lysosomal metabolic plasticity in tumors and in macrophages.
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide. The tumor microenvironment (TME) is a highly immunosuppressive niche shaped by aberrant angiogenesis, chronic inflammation, and extracellular matrix remodeling, which facilitates immune evasion and promotes HCC proliferation,...
A novel mechanism by which FOXP1 transcriptionally upregulates NUSAP1 expression results in glycolytic metabolic reprogramming that induces TAM M2 polarization and promotes HCC progression, identifying a potential therapeutic avenue for reversing the immunosuppressive microenvironment in HCC.
This study aimed to identify the role of thrombospondin 1 (THBS1) in gastric cancer (GC) with peritoneal metastasis (PM) as a model of aberrant interorgan communication between gastric carcinoma and the peritoneal microenvironment. Bulk, single‐cell, and spatial transcriptomics were performed to identify m...
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
