AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
Understanding the crosstalk between cytoskeletal mechanics and inflammatory signalling may reveal novel regulatory mechanisms and identify promising therapeutic targets for rheumatoid arthritis.
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by persistent synovitis, pannus formation, cartilage degradation, and bone erosion. Although conventional synthetic, biologic, and targeted synthetic disease-modifying antirheumatic drugs have improved disease control, many patients fail t...
Osteoarthritis (OA) is a whole-joint disease involving cartilage, synovium, subchondral bone, and neurovascular structures. Synovitis, damage-associated molecular patterns, and interactions between macrophages and fibroblast-like synoviocytes have been widely studied. However, a tissue-level explanation is still lackin...
Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes long-term destruction of cartilage and leads to irreversible arthritis. Pro-inflammatory messengers such as interleukin-1 beta (IL-1 beta), tumour necrosis factor-alpha (TNF alpha), interleukin-6 (IL-6), and interleukin-17 (IL-17)—drive this destruct...
The data suggests that the high levels of CD248 expression seen on synovial fibroblasts provides a protective brake that attenuates bone damage by preventing the polarisation of emergent fibroblasts towards a destructive phenotype.
Osteoarthritis (OA) has conventionally been considered a degenerative mechanical condition; but an increasing number of studies support an alternative perception of this disease as one characterized by impaired immune homeostasis in the joint environment. The purpose of this review is to analyze the mechanisms of how t...
Approximately 5% to 20% of patients with rheumatoid arthritis (RA) fail to respond to sequential biologic and targeted synthetic disease-modifying antirheumatic drugs, representing a major unmet clinical need. Increasing evidence indicates that a substantial proportion of these patients exhibit a pauci-immune (fibroid)...
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.