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Molecular subtyping of colorectal cancer based on aging-related gene network perturbation analysis and functional validation of MAP1B

Wu Ning Shuai-Xi Yang Nan Qiao Lei Zhou Zong-Ze Li Lin Zhang Zhe Zhang

Aug 2026 · Translational Oncology · Vol 72 · 0 citations · 32 references

Medicine

TL;DR

Ageing-gene network perturbation defines three colorectal cancer subtypes and silencing MAP1B curbs invasion and migration and shrinks mouse tumors.

Abstract

Highlights • Aging-gene network perturbation defines three colorectal cancer subtypes.• Stromal-invasive and lipid-driven subtypes fare worse than the proliferative one.• MAP1B ranks first across six cohorts and rises with stage and metastasis.• Silencing MAP1B curbs invasion and migration and shrinks mouse tumors.• MAP1B-high tumors favor dasatinib, which adds to the effect of MAP1B loss.

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