How the vitamins’ potential is at stake to reach the clinical perspective is highlighted, along with different strategies to overcome their limitations using novel drug delivery and biomarker-based approaches.
This review systematically elaborates the potential molecular mechanisms through which KD protects against PD, which covers the improvement of cerebral energy metabolism, antioxidant and anti-apoptotic activities, suppression of neuroinflammation, regulation of α-synuclein pathological aggregation, and modulation of gu...
Mula A, Yan Bai, Yu-Lin Wang et al.· Frontiers in Nutrition· 0 citations
This review critically examines OS-mediated mechanisms underlying major NDs and emphasizes the therapeutic potential of designed multi-functional antioxidants as next-generation neuroprotective agents.
Kuleshwar Sahu, Rakesh Sahu, Mahima Mishra et al.· Mini-Reviews in Medical Chem...· 0 citations
Klotho is a promising neurochemical modulator with disease-modifying properties in HD, and its multifunctional protective activities are consistent with important pathological markers of HD, necessitating more preclinical and clinical studies to confirm its translational value.
Shikha Singh, Avnesh Kumar, Falguni Goel et al.· Current molecular medicine· 0 citations
This review summarizes the major causes of neurodegeneration, recent developments in advanced cell-based in vitro models, and commonly employed neuroprotective assays, highlighting their importance in the discovery of novel therapeutic agents for neurodegenerative diseases.
D. A. Helen Sheeba, J. R, J. K et al.· International Journal of Res...· 0 citations
Several promising epidemiological trials linked high dietary intake of vitamins C and E to a reduced risk of Parkinson’s disease, and plant-derived antioxidants such as polyphenols were explored for their ability to combat neuroinflammation and reduce cognitive decline.
K. Jomová, S. Alomar, Richard Valko et al.· Archives of Toxicology· 0 citations
