Neurological disorders are a major global health challenge in the current era, and they need new therapeutic treatments.
We read with interest the Viewpoint by Percetti and colleagues proposing the concept of a biologically de fi ned mitochondrial subtype of Parkinson ’ s disease (PD) ( “ MitoPD
A graphical overview of the screening of 746,000 compounds for the inhibitory effects of α-synuclein aggregation gives rise to identification of novel inhibitors of α-synuclein aggregation that may help develop a cure for Parkinson's disease.
The diazapyridinophane scaffold is established as a viable first-generation platform for blood–brain barrier (BBB)–permeable Mn2+ MRI contrast agents and both the bifunctional chelators and their Mn2+ complexes exhibit appreciable affinity for Aβ aggregates.
Oral SCA administration to APP/PS1 transgenic mice significantly improved spatial learning and memory and suppressed pro-inflammatory cytokines, and was associated with cognitive and neuropathological improvements alongside alterations in gut microbiota and hippocampal metabolism.
Obesity may increase Alzheimer's disease (AD) risk, yet the underlying mechanisms remain unclear.
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