Open access

Urolithin A Exerts Neuroprotective Effects Against Ischemic Stroke by Inhibiting Oxidative Stress and Neuroinflammation

Yanxin Shao Li-Na Feng Yanchun Li Yichen Cai Hui Yuan Qin Tang Ming-Feng Yang Weixia Yang Hong Shi Leilei Mao

Aug 2026 · CNS Neuroscience & Therapeutics · Vol 32 · 0 citations · 54 references

Medicine

Abstract

Ischemic stroke (IS), the main stroke type, causes neuronal injury via hypoperfusion and hypoxia, imposes heavy health burdens, and is characterized by neurological deficits driven by oxidative stress and inflammation.

DOI PubMed Semantic Scholar

Read PDF

Similar papers

Open access Aug 2026

Downregulation of Lgals3 Alleviates Inflammatory Response and Apoptosis in a Mouse Model of Cerebral Ischemia/Reperfusion Injury

The present work investigated the expression and function of Lgals3 in cerebral ischemia/reperfusion (cerebral IR) injury.

Zhao-Dan Gan, Hai-Fang Lai, Yun Yang et al. · Brain and Behavior · 0 citations

RETRACTED: NaHS Protects against the Impairments Induced by Oxygen-Glucose Deprivation in Different Ages of Primary Hippocampal Neurons

Using both young and aged primary cultured hippocampal neurons as in vitro models to study brain ischemia and neuroprotective agents for treatment purpose.

Aurel Popa-Wagner, Michelle A. Clark, Qian Ding et al. · 0 citations

Review Open access Aug 2026

Paeonol as a Multi‐Target Therapy for Neurological Disorders: Mechanistic Insights Into Neuroprotection

Neurological disorders are a major global health challenge in the current era, and they need new therapeutic treatments.

Md. Sakib Al Hasan, Naznin Shahria, Yasin Emon et al. · Immunity, Inflammation and D... · 0 citations

Open access Aug 2026

Cholesterol Drives IFITM3 + Microglia Activation and Induces STING Mediated Neuroinflammation After Ischemic Stroke

Dysregulated microglial cholesterol metabolism has been implicated in post‐stroke neuroinflammation, yet the specific pathogenic microglial subpopulations, their molecular signatures, and the downstream inflammatory cascades remain poorly defined.

Yue-lei Cheng, Yuxi Zhou, Yong-Hui Chen et al. · CNS Neuroscience & Therapeut... · 1 citation

Editorial Open access Aug 2026

Editorial for the Special Issue “Molecular Mechanisms and Treatment of Ischemia–Reperfusion Injury”

Ischemia-reperfusion injury (IRI) remains one of the most challenging obstacles in modern medicine, influencing outcomes across cardiovascular disease, organ transplantation, stroke, peripheral ischemia, and acute surgical conditions [...].

Jun Kobayashi · Current Issues in Molecular... · 0 citations

Open access Aug 2026

Scutellarin Alleviates Neuronal Apoptosis After Ischemia and Hypoxia via the HIF‐1α–CX3CR1 Axis

Stroke is a significant health threat characterized by high incidence, mortality, disability, recurrence, and complications. Over 70% of strokes are ischemic in nature. Reducing neuronal apoptosis following ischemic–hypoxic injury is crucial for effective treatment. This study investigates the direct neuroprotective ef...

Jing-Chun Pei, Bin Hu, Zhong-Hui Wen et al. · CNS Neuroscience & Therapeut... · 0 citations