TL;DR
The results support the use of the IL-6 variation in the diagnosis and genetic screening of NHL but not for therapeutic choices, and suggest that individuals carrying the G allele may be at twice the risk of developing NHL compared with those carrying the C allele.
Endometriosis is a chronic inflammatory disorder with a complex genetic etiology. The interleukin-17 (IL-17) family, particularly IL-17 A and IL-17 F, plays a critical role in driving pro-inflammatory responses within the peritoneal cavity. This case-control study investigated the association of IL17A rs2275913 and IL1...
Background: Takayasu arteritis (TA) is a large-vessel vasculitis with an incompletely understood pathogenesis, in which genetic factors are thought to play an important role. Cytokine-mediated immune pathways, particularly those involving Th1 and Th17 responses, have been implicated in the immunopathogenesis of TA, mak...
The immunoregulatory cytokine interleukin (IL)-35 has been implicated in the pathogenesis of hepatocellular carcinoma (HCC). Here, we explored the association between single-nucleotide polymorphisms (SNPs) in the IL-35 gene and the occurrence of HCC in patients with chronic hepatitis B virus (HBV). We sele...
INTRODUCTION Among the non-HLA loci, ERAP1 and IL-23R gene polymorphisms have been implicated in spondyloarthritis (SpA). This study aimed to determine their association in a Tunisian cohort and to assess their influence on disease characteristics. METHODS We genotyped 100 SpA patients and 100 sex- and region-matched...
The findings demonstrate an association between the IL-4 rs2243250 polymorphism and allergic rhinitis, together with alterations in inflammatory markers and leukocyte profiles, which may contribute to understanding susceptibility to allergic rhinitis.
OBJECTIVES Brucellosis is recognized as one of the most widespread zoonotic diseases, caused by facultative intracellular coccobacilli of the genus Brucella. Interleukin-27 (IL-27) is a pleiotropic cytokine that serves a critical role in the development of immunity against Brucella. IL-27 single nucleotide polymorphism...
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