Aug 2026· Cardiovascular Drugs and Therapy· 1 citation· 44 references
Medicine
TL;DR
This review proposes a hypothesis-generating conceptual framework that categorizes SHS into three endophenotypes, including neurogenic arrhythmic (Type I), inflammatory thrombotic (Type II), and metabolic remodeling (Type III), and potential phenotype-specific interventions include beta blockers for neural stabilization, NETs degradation for immunomodulation, and metabolic pathway antagonists.
Renin–angiotensin system inhibitors, sodium–glucose cotransporter-2 inhibitors, finerenone, and glucagon-like peptide-1 receptor agonists improve cardiorenal outcomes and have plausible anti-inflammatory actions, although inflammatory mediation remains unproven.
Aris Tsalouchos, P. Dattolo· Journal of Clinical Medicine· 0 citations
BACKGROUND
Cardiovascular diseases remain the leading cause of global morbidity and mortality, with pathogenesis extending beyond hemodynamic derangements to involve chronic, maladaptive immune-metabolic crosstalk. Macrophage functional identity has evolved beyond the M1/M2 paradigm toward a model of high heterogeneity...
Ke Yang, Xuefang Ma, Binyan Wang et al.· Journal of Advanced Research· 0 citations
The present review systematically outlines the clinical manifestations, core pathogenic mechanisms and emerging therapeutic strategies for CKD‑associated encephalopathy, and the targeted interventions on the gut‑kidney‑brain axis.
Nanling Zeng, Ling Jiang, Yang Zhang et al.· Molecular Medicine Reports· 0 citations
Ischemic stroke (IS) prognosis is frequently compromised by secondary systemic and neuropsychiatric complications extending beyond the initial brain injury. The hypothalamic–pituitary–adrenal (HPA) axis, the primary neuroendocrine regulator, plays a pivotal yet underappreciated role in the pathogenesis of these sequela...
Han Gong, Dan Liu, Xiang-Zheng Wang et al.· Frontiers in Human Neuroscie...· 0 citations
Stroke is a complex and highly heterogeneous acute cerebrovascular disease characterized by high incidence, disability rates, and mortality. The occurrence of a stroke is the result of a series of chain reactions. Neuroinflammation, as a core component of the pathological process of stroke, serves as the dynamic hub of...
Lili Teng, Minmin Wu, Wenjing Song et al.· Journal of Translational Med...· 0 citations
Background Acute ischemic stroke and cardiac dysfunction engage in a complex bidirectional interplay that critically determines patient outcomes. Despite growing recognition of the brain-heart axis, a comprehensive mechanistic framework integrating traditional and emerging pathways remains lacking. Moreover, existing r...
