TL;DR
The results suggest that IL7R may be associated with disease susceptibility and proteinuria in childhood IgAN.
Background/Aim: Interleukin-4 (IL-4) is a key T-helper 2 cytokine involved in immune regulation, allergic responses, and hematological malignancies. Although aberrant IL-4 expression has been implicated in acute lymphoblastic leukemia (ALL), the contribution of IL-4 genetic polymorphisms to childhood ALL susceptibility...
New insights are offered into the immunogenetic foundation of RSA and may reveal potential targets for therapeutic intervention in at-risk women.
Idiopathic nephrotic syndrome (INS) is the most common chronic glomerular disorder in children and is characterized by a variable response to corticosteroid therapy. Interleukin-38 (IL-38), an anti-inflammatory cytokine, and its gene polymorphisms may influence disease susceptibility and treatment outcomes. This study...
The observed associations suggest that PTPN22 polymorphism may contribute to disease heterogeneity and disease course in selected JIA subgroups, particularly in p-JIA.
The findings support the potential role of IL12B in genetic susceptibility to Takayasu arteritis and suggest possible population-specific genetic effects, while other examined cytokine gene polymorphisms showed no statistically significant association.
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