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PDE4D-CXCL13 axis in gland epithelial cells promotes B cell infiltration in primary Sjögren's syndrome.

Ru-hong Fang Meiyue Lu Han-Shuang Liang Xue-Jie Hu Liu-Wei Chu Chang Shu Lan-Qi Du Yu-Lin Jiang Yan Cheng De-Yun Liu Xue-Lan-Ting Li Ling Yao Xiang Lin Xu Li Pai-pai Guo Qing-Tong Wang
Aug 2026 · Acta Pharmacologica Sinica · 0 citations · 52 references
Medicine

TL;DR

It is reported that phosphodiesterase 4D (PDE4D) is markedly up-regulated in glandular epithelial cells from both pSS patients and murine models, correlating tightly with diminished saliva output and heightened B cell infiltration.

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