TL;DR
Small cell neuroendocrine carcinoma (SCNEC) included in poorly differentiated G3 neuroendocrine neoplasm, which is aggressive malignancy having clinical features & pathology similar to conventional squamous cell carcinoma of cervix.
ABSTRACT Primary small cell carcinoma of the esophagus (SCCE) is an infrequent aggressive neuroendocrine malignancy. We describe a 60-year-old woman with cirrhosis who presented with weight loss, backache, and night sweats. Histopathology confirmed small cell carcinoma of the esophagus with synaptophysin positivity and...
Primary vaginal cancer is a rare entity, accounting for 1% - 2% of gynaecological malignancies, with squamous cell carcinoma and adenocarcinoma comprising 80% - 85% and < 10% of cases, respectively. Adenocarcinoma is generally a clear cell histology, with intestinal differentiation being an exceptionally rare neoplasm,...
Advances in genetic studies, tumor grading, and targeted therapy have improved diagnosis and management of medullary thyroid carcinoma and enhanced precision-based management and outcomes in advanced RET-mutated tumors.
Morphology and specimen-specific immunophenotyping, integrated with specialist consultation, supported small cell carcinoma; POU2F3 nuclear positivity supported subtype assignment and explained the neuroendocrine-low phenotype rather than establishing the diagnosis alone.
Background: Neuroendocrine neoplasms (NENs) of the breast are rare, heterogeneous malignancies varying from well-differentiated neuroendocrine tumours (NETs) to poorly differentiated neuroendocrine carcinomas (NECs). Diagnosis is challenging due to histo - pathologic overlap with invasive breast carcinoma of no special...
Cancer of unknown primary (CUP) is a rare subtype of malignant tumor. When it presents as pelvic squamous cell carcinoma (SCC), the difficulty of clinical diagnosis and treatment increases significantly. Notably, some such pelvic SCC cases are confirmed to be associated with human papillomavirus (HPV) infection, ye...
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