TL;DR
In vivo antitumor studies demonstrate that PFD released in situ remodels TME by downregulating hyaluronic acid and type I collagen expression, normalizing tumor vasculature, improving intratumoral oxygen perfusion and contributing to amplified PDT.
Porphyrin-based photosensitizers (PSs) are among the most widely explored agents for photodynamic therapy (PDT), yet their clinical translation is severely limited by poor biocompatibility, aggregation-induced quenching, insufficient tumor selectivity, and the intrinsic reactive oxygen species (ROS) resistance of cance...
Combinational photodynamic and immune checkpoint blockade (PDT/ICB) therapy is a promising approach for oncotherapy. However, the tumor microenvironment (TME) poses multiple biological barriers that can critically undermine the treatment outcomes of PDT/ICB. To this end, a cascade-amplified photodynamic immunotherapy n...
Photothermal therapy (PTT) offers the advantages of noninvasiveness and high selectivity, while chemotherapy shows potent antitumor activity. However, their standalone applications are limited by insufficient photothermal ablation efficacy and chemotherapeutic resistance, respectively. To address these challenges, we...
Background Photodynamic therapy (PDT) eliminates malignancies through spatially controlled reactive oxygen species (ROS) generation and has achieved clinical success in localized tumors. Nevertheless, its therapeutic potential is severely restricted by the poor aqueous solubility, suboptimal ROS generation efficiency,...
This work reports a novel strategy for developing a theranostic nanoplatform for long-lasting PDT activated by 1530 nm laser irradiation and glutathione (GSH)-triggered carbon-centered radical synergistic therapy that responds specifically to the TME.
Photodynamic therapy (PDT) is a minimally invasive and low-toxicity strategy for tumors and bacterial infections. However, conventional small-molecule photosensitizers have poor water solubility, severe aggregation-caused quenching and weak tumor targeting, restricting their clinical translation. Macrocyclic host-guest...
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