TL;DR
By inhibiting the JAK1/STAT1 pathway, BHB promotes microglia M2 polarization and enhances their phagocytosis, attenuates neuroinflammation and neuronal injury, and ultimately exerts anti-EP effects.
Elevated endogenous BHB under obese conditions exerts neuroprotective effects against CIRI, and exogenous BHB can mimic this effect.
Tet alleviates hypoxia-induced microglial M1 polarization and microglia-mediated photoreceptor cell injury, at least partly through modulation of NF-κB/p65 signaling, which identifies Tet as a candidate compound for further preclinical investigation in retinal neuroinflammation associated with DR.
Tβ4 exerts neuroprotective effects against ACI by suppressing the TLR4/NF-κB signaling pathway and mitigating neuronal pyroptosis and mitigating neuronal pyroptosis, demonstrating potential clinical application value.
Objective Neuroinflammation plays an important role in the initiation and progression of central nervous system (CNS) disorders. Calycosin (Caly) has been reported to exert anti-inflammatory and neuroprotective effects. However, little is known about its potential role in microglia-mediated neurotoxicity and the underl...
Microglial TREM1 represents a key therapeutic target, supporting the clinical application of HXF for ischemic stroke, and HXF alleviates neuroinflammation and neuronal pyroptosis by inhibiting microglial M1 polarization through the TREM1/DAP12 pathway.
Microglial-mediated neuroinflammation is a core driver of brain disorders. Thus, modulating microglial activity is a critical therapeutic goal. In this study, we explored how Ginsenoside Rg1 (Rg1) protects against the inflammation seen in Parkinson's disease (PD). Our experiments utilized MPTP-challenged mice and lipop...
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