Magnolol mitigates neuroinflammation via NF-κB/IL-6/IL-1β pathways in AlCl₃-induced Alzheimer’s disease: insights from in-vivo and in-silico investigations
Results show that magnolol has important neuroprotective effects by reducing oxidative stress and inhibiting important inflammatory mediators, underscoring its potential as an effective treatment option for AD.
6-OH-F ameliorates Aβ-induced cognitive impairment by attenuating oxidative stress, neuroinflammation, and pyroptotic signaling, potentially through modulation of the TLR4/NF-κB/NLRP3 pathway, highlighting its therapeutic potential in Alzheimer's disease.
Unlike L-DOPA’s direct dopaminergic stimulation, tVB’s neuroprotective efficacy is mediated through multilevel regulation of key PD pathogenetic pathways, including neuroinflammation, oxidative stress, and impaired proteostasis.
Evgeniy A. Pislyagin, I. Manzhulo, Irina Agafonova et al.· Antioxidants· 0 citations
Chronic neuroinflammation is implicated in the pathogenesis of Parkinson's disease (PD), contributing to progressive dopaminergic neuron loss. Cobrotoxin (CoTX), a short-chain α-neurotoxin isolated from Naja atra venom, exerts anti-inflammatory and analgesic effects in several inflammation-related disease models. Howev...
Chun-Ze Yu, Shuyang Ma, Yuzhihan Cao et al.· International Immunopharmaco...· 0 citations
Evidence is provided that overdose FA supplementation may exert pro-inflammatory effects by promoting the NF-κB pathway, oxidative stress, and apoptosis in the context of ALS.
Yan-Bo Zhu, Yalun Zhang, Tao-Tao Yan et al.· Free radical research· 0 citations
In vitro studies show that IL-1β can play a possible detrimental role in facilitating neuropathogenesis, as seen in Alzheimer’s and Parkinson’s disease, and anti-inflammatory drugs Ibuprofen and Flurbiprofen have a potential role in modulating the neuroinflammation in MS.
Jagadeesh Narasimhappagari, Ling Liu, W. S. T. Griffin· Current Issues in Molecular...· 0 citations
