Case report

A closer look at LATE: a Case Report on a subtly evolving neurodegenerative disorder

Maria Luisa Di Giesi F. Motolese D. Norata Elisabetta Sapio S. Selvaggi G. M. Meduri F. Capone Fabio Pilato V. di Lazzaro

Oct 2026 · Neurological Sciences · Vol 47 · 0 citations · 12 references

Medicine

TL;DR

The slowly progressing isolated amnestic profile, medial temporal–predominant neurodegeneration, high CSF NfL level, and persistently negative AD biomarkers supported the diagnosis of LATE and should be actively considered in elderly patients with a hippocampal-type amnestic syndrome and negative AD biomarkers.

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