LncRNA PRR34-AS1 Promoted the Neuroinflammation of Ischemic Stroke via Regulating miR-532-3p

MiR-590-3p Targets HMGB1 to Alleviate Endothelial Injury Induced by β2GPI/Anti-β2GPI Immune Complex.

BACKGROUND As a systemic autoimmune condition, antiphospholipid syndrome (APS) currently lacks robust biomarkers for accurate diagnosis. While microRNAs (miRNAs) show promise as diagnostic and therapeutic targets, the specific function of miR-590-3p in APS pathogenesis is still unknown. OBJECTIVE This study investiga...

LncRNA NR2F1-AS1 serves as a diagnostic biomarker for diabetic peripheral neuropathy and promotes disease progression by regulating miR-150-5p.

NR2F1-AS1 serves as a potential non-invasive biomarker and promising therapeutic target for DPN by driving Schwann cell dysfunction via the NR2F1-AS1/miR-150-5p/TP53 axis.

LncRNA UCA1 Aggravated Microglia-mediated Neuroinflammation After Traumatic Brain Injury by Targeting miR-708-5p.

lncRNA TUG1 mediates palmitic acid-induced neuronal lipotoxic injury via the miR-449a-5p/caspase-3 and Akt/GSK-3β axes

Findings establish a causal axis in which lncRNA TUG1 derepresses caspase-3 and suppresses Akt/GSK-3β signaling by sponging miR-449a-5p, thereby driving neuronal lipotoxic injury.

Study on the Expression of MiR-642b-3p in Spontaneous Intracerebral Hemorrhage and Its Regulatory Mechanism on Endothelial Cell Injury

MiR-642b-3p is upregulated in sICH and mediates thrombin-induced endothelial cell injury, at least in part, by targeting CCNA2.

Downregulation of miR-33a-5p regulates TNF-α/NF-κB signaling and is associated with reduced diabetic neuropathic pain through targeting SIRT6.

BACKGROUND The pathogenesis of diabetic neuropathic pain (DNP) remains unclear, with neuroinflammation mediated by abnormal TNF-α/NF-κB pathway activation being a key factor. This study aims to elucidate how this pathway contributes to DNP. METHODS miR-33a-5p levels were measured via qPCR in the serum of diabetic pat...