Postbiotic-Mediated Regulation of Inflammation in Osteoarthritis: An In Vitro Study

Hyaluronic Acid Modulates IL1β-Induced Cytokine Profile of Gingival Mesenchymal Stem Cells.

HA suppressed pro-inflammatory cytokines while up-regulating IL-10 in IL-1β-exposed gMSCs, restoring cell viability and accelerating wound closure under inflammatory conditions, which support the rationale for HA's clinical use in periodontal therapy.

Lipopolysaccharide-induced inflammatory modulation of the apoptotic pathways in human primary aniridia limbal stromal cells, in vitro

Purpose This study investigated apoptosis-related responses to a standardized 24-hour lipopolysaccharide (LPS) challenge in primary limbal stromal cells (LSCs) derived from patients with congenital aniridia (AN-LSCs) and control donors. Methods LSCs were isolated from limbal tissue obtained from patients with congenita...

The IL-4/IL-4R/STAT6 signaling axis regulates macrophage efferocytosis in osteoarthritis

Sophoraflavanone G decreases the migratory ability of cancer cells by altering the cytokine profile of the environment in endometrial cancer and macrophage co-culture

Background : Macrophages play key roles in initiating, sustaining, and resolving inflammation. Sophora flavescens has traditionally been used as a herbal anti-inflammatory treatment for inflammation-related conditions. This study aimed to investigate how sophoraflavanone G (SF-G) modulates the inflammatory response in...

Depletion of PTGS1 Inhibits IL-1β-Induced Inflammatory Responses and Osteoblast Dysfunction in MC3T3-E1 Cells via the Wnt/β-Catenin Pathway

In vitro findings suggest that PTGS1 may modulate osteoblastic responses under inflammatory conditions; however, further validation is required before any conclusion regarding TMJ-OA can be drawn.

CD147 is associated with NF-κB activation during the post-traumatic immune response in a murine trauma model

Extracellular matrix metalloproteinase inducer (CD147) has been proven to play a crucial role in a variety of inflammatory diseases but has not yet been investigated in trauma. The aim of the study was to investigate the role of CD147 in a murine model of trauma and hemorrhagic shock (TH) on the activation of NF-κB, as...