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Prognostic Markers in Meningioma: Effectiveness of FISH‐Assessed CDKN2A/B Homozygous Deletion and Limits of Surrogate p16/MTAP Immunohistochemistry in Predicting Disease‐Specific Survival

A. Ricci Filippo Nozzoli Alessandro Biale C. Tampieri Ludovica Verdun di Cantogno D. Garbossa M. Levis R. Rudà C. Bonaudo A. della Puppa L. Livi I. Desideri P. Cassoni L. Bertero
Sep 2026 · Neuropathology and Applied Neurobiology · Vol 52 · 0 citations · 23 references
Medicine

TL;DR

This study evaluated multiple CDKN2A/B FISH cutoffs and assessed the diagnostic and prognostic performance of MTAP and p16 IHC.

Abstract

Homozygous deletion (HD) of CDKN2A/B represents an adverse prognostic biomarker in meningiomas and a diagnostic criterion for CNS WHO grade 3 assignment. However, fluorescence in situ hybridisation (FISH) thresholds and the role of immunohistochemistry (IHC) surrogates remain uncertain. This study evaluated multiple CDKN2A/B FISH cutoffs and assessed the diagnostic and prognostic performance of MTAP and p16 IHC.

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