Journal of Pediatric Neurological Disorders

Cuproptosis in Ischemic Stroke: Molecular Mechanisms and Therapeutic Potential

The molecular mechanisms of cuproptosis and its potential involvement in cerebral ischemia are summarized, and the therapeutic potential of cuproptosis-targeting agents for improving neurological outcomes after stroke is discussed.

Literature Review: Thrombolysis In Patients With Acute Ischemic Stroke

Thrombolysis plays a role in restoring cerebral blood flow through thrombus lysis, one of the main therapies that provides optimal benefits when administered as early as possible to patients who meet the appropriate criteria.

Journal of Population Therapeutics and Clinical Pharmacology

A stroke is a sudden disruption of the cerebral circulation or perfusion. Intracerebral hemorrhages (ICH) account for about 10 percent of strokes. For the treating physician to determine the location and extent of hemorrhages, evaluate the likelihood of an imminent brain injury, and establish a treatment plan, neuroima...

Journal of Pediatric Neurological Disorders

Time is Brain: A Scoping Review of Barriers to Timely Thrombolysis in Ischemic Stroke

Introduction: Ischemic stroke is a medical emergency that requires treatment to be initiated within the first 4.5 hours, which is the therapeutic window for alteplase to minimize the onset of severe and irreversible sequelae. Although studies on its management exist, gaps remain in the systematic analysis of the factor...

Biomarkers of chronic cerebral ischemia as a prospect for personalization of the surgical approach in its treatment. Literature review

Introduction . Chronic cerebral ischemia is a multifactorial pathological condition characterized by a gradual reduction in cerebral blood flow and the development of focal neurological deficits, ranging from cognitive impairments to motor and speech disorders. Furthermore, against the background of existing chronic...