TL;DR
A targeted multifunctional nanotherapeutic platform by integrating ferroptosis induction, gene modulation, and chemotherapeutic intervention with highly sensitive and selective miRNA-21 sensing capability is established, laying the groundwork for precision tumor therapy.
Ferroptosis is an iron-mediated cell death process driven by lipid peroxidation, yet its antitumor potential is often counteracted by the limited endogenous H2O2 content, the strict catalytic conditions required for the Fenton reaction, and protective autophagy. Notably, sustained autophagy drives ferritin degradation...
The DDS provides a promisingly transformable therapeutic platform for drug resistant cancers, and for targeting other and multiple oncogenic miRNA-21 and multiple oncogenic miRNAs.
The developed carbon-based nanoplatform showed significant tumor specificity and inhibition, making it a significant approach for a potential multifunctional treatment strategy for cancer.
Cerium molybdate-doped polyaniline nanoparticles are developed to enable a synergistic combination of photothermal therapy (PTT) and CDT, thereby triggering immunogenic cell death (ICD) and enhancing antitumor immunity and presenting a robust nanoplatform integrating chemodynamic and photothermal therapies for potent c...
An upregulated GPX4 level of tumor cells with enhanced antioxidant defense systems accounts substantially for cisplatin resistance, but on the other hand, offers a unique therapeutic strategy due to the improved sensitivity of tumor cells to ferroptosis. Effective ferroptosis induction remains a challenge owing to insu...
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