This dedicated review presents the latest advancements in the field of miRNA diagnostics and unravels the contributions of nanozymes in miRNA sensing and highlights two major approaches commonly used for miRNA detection in sensors; assisted through nucleic acid amplification, and amplification-free approaches.
An electrochemical biosensor that enables sensitive and specific detection of exosomes without the requirement of pretreatment steps and signal amplification is reported, demonstrating its potential for early diagnosis of the cancer.
BACKGROUND
The early and accurate detection of miRNA-21 is of great significance for both lung cancer diagnosis and livestock health monitoring, given its conserved sequence across mammals. Herein, we report an enzyme-free electrochemical biosensor based on surface-initiated ring-opening metathesis polymerization (ROMP...
Dan Qin, Shi-Jin Zhou, D. Tsendjav et al.· Analytica Chimica Acta· 0 citations
MicroRNAs (miRNAs) represent highly promising biomarkers for non-invasive clinical diagnostics. To overcome the limitations of conventional methods, Field-Effect Transistor biosensors (bioFETs) emerge as compelling alternatives by providing label-free and real-time readouts. However, bioFETs employing canonical DNA/RNA...
Francesco Lavecchia di Tocco, A. Bizzarri· Chemosensors· 0 citations
This review provides a comprehensive overview of the latest advancements and current trends in nano-biosensor technology as a promising tool in cancer diagnostics.
J. Dash, G. Pattnaik, Subhranshu Acharya et al.· Current Drug Therapy· 0 citations
An efficient workflow based on hybridization chain reaction (HCR) is developed to specifically extend the target miRNA and conduct single-molecule analysis within solid-state nanopores and is expected to provide an easy and robust pathway for enhanced sensing of small nucleic acids using solid-state nanopores.
Chong-Xin Tao, Xun-Yu Zheng, Chang-Hui Xu et al.· Small Methods· 0 citations
This work highlights strategies specifically designed for epithelial-mesenchymal transition (EMT)-associated CTC phenotypes and explores AI- and IoT-enabled implementations for decentralized oncology, and a comprehensive evaluation of electrochemical approaches for CTC and ctDNA detection.
Tuğba Ören Varol, Mehmet Varol· Annals of Biomedical Enginee...· 0 citations
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